Nedocromil Sodium

A to Z Drug Facts

Nedocromil Sodium

  Action
  Indications
  Contraindications
  Route/Dosage
  Interactions
  Lab Test Interferences
  Adverse Reactions
  Precautions
Patient Care Considerations
  Administration/Storage
  Assessment/Interventions
  Patient/Family Education


(NEH-doe-KROE-mill SO-dee-uhm)
Alocril, Tilade, Mireze
Class: Respiratory inhalant

 Action Inhibits release of mediators from inflammatory cell types associated with asthma, including histamine from mast cells and betaglucuronidase from macrophages. May also suppress local production of leukotrienes and prostaglandins. Inhibits development of bronchoconstriction responses to inhaled antigen and other challenges such as cold air.

 Indications Maintenance of mild to moderate bronchial asthma; treatment of itching caused by allergic conjunctivitis.

 Contraindications Standard considerations.

 Route/Dosage

SYMPTOMATIC ADULTS & CHILDREN > 12 YR: Aerosol inhalation 2 inhalations 4 times daily at regular intervals to provide 14 mg/day. May attempt lower frequency of doses (twice daily to 3 times daily) over several weeks in well-controlled patients.

 Interactions None well documented.

 Lab Test Interferences None well documented.

 Adverse Reactions

CNS: Headache. EENT: Ocular burning; irritation and stinging; unpleasant taste; nasal congestion; conjunctivitis; eye redness; photophobia. GI: Nausea; vomiting; dyspepsia; abdominal pain. RESP: Rhinitis; upper respiratory tract infection; asthma. OTHER: Unpleasant taste.

 Precautions

Pregnancy: Category B. Lactation: Undetermined. Children (aerosol inhalation): Safety and efficacy in children < 12 years of age not established. Children (ophthalmic): Safety and efficacy in children < 3 years of age not established. Acute bronchospasm: Should not be used for reversal of acute bronchospasm, particularly status asthmaticus. However, continue to administer during acute exacerbations, unless patient becomes intolerant to inhaled dosage forms. Cough/Bronchospasm: If cough or bronchospasm follows inhalation, may need to discontinue. Dosing interval: Optimal effect depends on administration at regular intervals, even during symptom-free periods.


PATIENT CARE CONSIDERATIONS


 Administration/Storage

 Assessment/Interventions

 Patient/Family Education

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© 2003 Facts and Comparisons
David S. Tatro
A to Z Drug Facts